|
PharmOptima focuses on the mid to late phases of drug discovery between
target identification and selection of lead compounds, helping clients
select the best candidates to accelerate drug development and increase
chances for clinical success. We also provide consultation and laboratory
support for target selection and high throughput screening (HTS) assays.
Our clients save money and time by selecting the best drug candidates
and identifying potential problems early, before costly animal safety
and first in man testing.
PharmOptima's 10 founding scientists have a successful R&D track record in
cardiovascular, CNS, cancer, dermatology, and infectious diseases;
over 300 cumulative years experience; 325 publications; and
inventors on 14 patents. These scientists average over 20 years R &
D experience in the pharmaceutical industry. With experts in
Biochemistry/High Throughput Screening, in vivo Pharmacology, and ADME the company functions as a Drug Discovery/Development Program
Project Team. This Project Team approach provides clients with
multidisciplinary input to solve R & D problems.
PharmOptima's scientific staff has grown to over 30, with most
scientists having more than 10 years of Drug Discovery/Development
experience covering a wide variety of disciplines.
PharmOptima's Pharmacology/ADME scientists are knowledgeable in
the requirements for successful drug discovery and registration with
broad experience in drug discovery including in vivo model development,
pharmacology, bioanalytical, ADME, PD/PK, and drug-drug interaction
studies. Their expertise includes developing analytical
assays for new compounds, validating these assays, and analyzing
compounds in test articles and biological matrices. These
scientists were involved with many IND or NDAs filed by Upjohn
through Pharmacia through 2003 and collaborated on regulatory approvals for 12 marketed
products. PharmOptima's ADME scientists have operated in a GLP
environment since 1993. PharmOptima's Biochemistry/HTS scientists
are experienced in drug discovery assay development, enzyme
kinetics, protein purification, HTS, and data analysis.
Our new laboratory is well equipped and licensed for
radioisotopes and controlled substances. Our analytical
instrumentation includes HPLC with DAD/UV, radioactivity and
fluorescence detection, LC-MS-MS (5) & GC-MS-MS (2), Thermo and
SCIEX platforms, plate readers, and robotics. Two new TSQ
Quantums with UHPLC capability are currently IQ/OQed and operating
in our new labs. PharmOptima's analytical labs are GLP
compliant.
|
